There is no cure for Klinefelter's because the problem lies within the chromosomes and there is not yet a way to fix that. But, generally males with Klinefelter's lead completely normal lives, as long as they closely monitor their health. They will lead mostly normal lives but they will be more susceptible to certain diseases and medical conditions. These include: obesity, osteoporosis (a condition that often causes brittle bones), Diabetes type I, lupus, hypothyroidism, and many heart conditions.